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Targeting an HIV-1 sequence in vivo by the hairpin ribozyme
(Northern Illinois University, 1992)
Ribozymes are small catalytic RNAs that can be engineered to cleave heterologous RNA in an enzymatic fashion. One of the applications of ribozyme technology is as an AIDS therapeutic. In this thesis, an HIV-1 sequence was ...
Targeting tobacco mosaic virus with a hairpin ribozyme
(Northern Illinois University, 1992)
In vitro studies suggest that catalytic RNA may down regulate gene expression through cleavage of target RNA. This application is being evaluated by using a "hairpin" ribozyme derived from the negative strand of the satellite ...