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In vivo repair of viral transcripts following cleavage by a cis hairpin ribozyme
(Northern Illinois University, 1996)
The hairpin ribozyme is a catalytic RNA that can be engineered to cleave any RNA with the sequence 5' GUC 3'. Because of this capacity to cleave targeted RNA, the hairpin ribozyme has the potential to down-regulate any ...
A hairpin ribozyme from a satellite RNA of chicory mottle virus : cleavage efficiency, substrate selectivity and targeting HIV1
(Northern Illinois University, 1996)
The catalytic capacity, substrate selectivity and application in HIV1 treatment of a hairpin ribozyme derived from sCYMVl were studied. Based on the sequence comparisons of hairpin ribozymes derived from sTRSV (GUC substrate) ...
Targeting tobacco mosaic virus with a hairpin ribozyme
(Northern Illinois University, 1992)
In vitro studies suggest that catalytic RNA may down regulate gene expression through cleavage of target RNA. This application is being evaluated by using a "hairpin" ribozyme derived from the negative strand of the satellite ...