Etiological Components and Patterns Contributing to the Development of Systemic Lupus Erythematosus
Kwaben, V. B.
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Intro: Systemic Lupus Erythematosus (SLE) is a multisystem inflammatory autoimmune disease that affects more than a quarter million people in the United States today. It involves a dysfunction within the humoral immune systems that leads the body to attack its own tissues mediating a chronic disease comprising episodes of exacerbations and remissions in which severe complications may occur. Background: Although the exact etiology of SLE is unknown, previous research has implicated a multitude of etiological components associated with SLE including genetic, hormonal, immunologic and environmental influences. In fact, research has found the development of SLE dependent upon the interaction of these components. The current literature review seeks to examine the underlying patterns and interactions of etiological components that contribute to the development of SLE. Methods: The following databases were used in completing searches: Google, Scholar, Pub Med (n=9), Europe PMC (n=8) and Wiley Online Library (n=2). Additionally, ancestry searches were used to locate articles (n=8). Results: Various factors were identified under each etiological category contributing to SLE. There is a prominent gene-environmental interaction that often triggers the disease and the hormonal-gene and gene-immunologic interactions are more often thought to progress the disease leading to further dysfunction of the immune system. Discussion: These results highlight the complexity and need of etiological interactions for SLE to develop. Despite the varying ways for the disease to begin, identification of susceptible genes for targeted gene therapy could lower the risk of SLE development. Further research is necessary to identify etiological components and corroborate the extent of interaction for SLE to develop.