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The Synthesis of Novel Boron Nanomaterials for Biomedical Application

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dc.contributor.advisor Hosmane, Narayan S. en_US Dominguez, Rebecca A., 1995--. en_US 2017-05-15T13:29:44Z 2017-05-15T13:29:44Z 2017-05
dc.description.abstract Boron Neutron Capture Therapy (BNCT) is one biomedical application in which boron nanomaterials are of crucial importance. Current research focuses on increasing the boron content and improving the cancer cell targeting in treatment agents. Thus, multiple routes of synthesizing functionalized boron nanoparticles were explored. Boron nanoparticles were synthesized by pyrolysis and functionalized with bromine. An alternate synthesis by sodium reduction was performed and those nanoparticles were functionalized with octanol and azido-PEG3-amine. The sugar 5-thio-D-glucose was modified for use as a targeting agent. The products of these reactions were characterized with Nuclear Magnetic Resonance Spectroscopy (NMR), Transmission Electron Microscopy (TEM), and Energy-Dispersive X-ray Spectroscopy (EDX). The syntheses were all successful to an extent, as indicated by the characterization. The boron nanoparticles synthesized by sodium reduction are particularly promising. Future work includes further purification of the products, additional characterization and linking the modified 5-thio-D-glucose molecule to the azido-PEG3-amine functionalized boron nanoparticles. en_US
dc.format.extent 25 pages en_US
dc.language.iso en_US en_US
dc.publisher Northern Illinois University en_US
dc.rights NIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors. en_US
dc.subject Boron Neutron Capture Therapy en_US
dc.subject Boron Nanoparticles en_US
dc.subject Cancer Therapy en_US
dc.title The Synthesis of Novel Boron Nanomaterials for Biomedical Application en_US
dc.type.genre Dissertation/Thesis en_US
dc.type Image en_US
dc.type Text en_US
dc.contributor.department Department of Chemistry and Biochemistry en_US B.A. (Bachelor of Arts) en_US

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