The Synthesis of Novel Boron Nanomaterials for Biomedical Application
Dominguez, Rebecca A., 1995--.
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Boron Neutron Capture Therapy (BNCT) is one biomedical application in which boron nanomaterials are of crucial importance. Current research focuses on increasing the boron content and improving the cancer cell targeting in treatment agents. Thus, multiple routes of synthesizing functionalized boron nanoparticles were explored. Boron nanoparticles were synthesized by pyrolysis and functionalized with bromine. An alternate synthesis by sodium reduction was performed and those nanoparticles were functionalized with octanol and azido-PEG3-amine. The sugar 5-thio-D-glucose was modified for use as a targeting agent. The products of these reactions were characterized with Nuclear Magnetic Resonance Spectroscopy (NMR), Transmission Electron Microscopy (TEM), and Energy-Dispersive X-ray Spectroscopy (EDX). The syntheses were all successful to an extent, as indicated by the characterization. The boron nanoparticles synthesized by sodium reduction are particularly promising. Future work includes further purification of the products, additional characterization and linking the modified 5-thio-D-glucose molecule to the azido-PEG3-amine functionalized boron nanoparticles.