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No association between perfluoroalkyl chemicals and hypertension in children

Show simple item record Geiger, Sarah Dee en_US Xiao, Jie en_US Shankar, Anoop en_US 2017-05-04T16:59:31Z 2017-05-04T16:59:31Z 2014-01-13
dc.identifier.citation Geiger SD, Xiao J, Shankar A. No association between perfluoroalkyl chemicals and hypertension in children. Integrated Blood Pressure Control. 2014;7:1-7. doi:10.2147/IBPC.S47660. en_US
dc.identifier.other 10.2147/IBPC.S47660
dc.description.abstract Background Hypertension is a leading cause of cardiovascular disease worldwide. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are perfluoroalkyl chemicals (PFCs) used in the manufacture of common consumer products and detected in the blood of the majority of Americans. Emerging biological data suggest that PFC exposure may have a role in the development of hypertension. However, the association between PFCs and hypertension has not yet been explored in humans. Therefore, we examined this association in a representative sample of US children. Methods A cross-sectional study was performed on 1,655 children from the National Health and Nutrition Examination Survey, 1999–2000 and 2003–2008. The main outcome of interest was hypertension, defined as age, height, and sex specific systolic and/or diastolic blood pressure level at the 95th percentile. Results We found no association between serum levels of PFOA and PFOS and hypertension in either unadjusted or multivariable-adjusted analyses controlling for age, sex, race-ethnicity, body mass index, annual household income, moderate activity, total serum cholesterol, and serum cotinine. Compared with the lowest quartile, the multivariable-adjusted odds ratio (95% confidence interval) of hypertension in the highest quartile of exposure was 0.69 (0.41–1.17) for PFOA and 0.77 (0.37–1.61) for PFOS (all P-trend values >0.30). Conclusion Our findings indicate that exposure to PFOA or PFOS is not significantly associated with hypertension in children at the lower PFC exposure levels typical of the general population. en_US
dc.language.iso en_US en_US
dc.publisher Dove Medical Press en_US
dc.subject perfluorooctanoic acid en_US
dc.subject perfluorooctane sulfonate en_US
dc.subject perfluoroalkyl chemicals en_US
dc.subject blood pressure en_US
dc.subject children en_US
dc.title No association between perfluoroalkyl chemicals and hypertension in children en_US
dc.type.genre Article en_US
dc.type Text en_US
dc.contributor.department School of Nursing and Health Studies en_US

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