DNA repair and a closer look at the role of Ku protein
Tumuliri, Srinivas S.
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Double strand breaks in cells may arise due to a number of reasons including mutagens and normal cellular processes such as V(D)J recombination. Unrepaired strand damage can result in broken chromosomes and cell death. Improper repair can lead to cancer. A specific component of nonhomologous recombination to repair DSBs was studied in two different cell lines, Chinese hamster ovary K1 cells and xrs cells. Xrs cells, deficient in Ku protein were impaired in their ability to repair DSBs induced by ionizing radiation. These results and other findings support the critical function of Ku in DSB repair and indicate a multiple roles of Ku in DNA metabolism.