DNA double-strand break induction by gamma radiation
Miller, Liam M.
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Radiation is a powerful tool in fighting breast cancer. However, the mechanism of cell killing is not fully understood. It is therefore important to characterize radiation so that it may be used more effectively. In the present study the relationship between gamma radiation and DNA double strand break induction is investigated. DNA double strand breaks are the focus of this study because the biological consequences of DNA double-strand breaks are significant, and can result in cell-killing/ apotosis (Heilmann 1995). DNA double strand break induction is surveyed using a constant-field gel electrophoresis approach previously described by J. Heilmann (Heilmann 1995). A linear increase in DNA double-strand breaks is reported here which is consistent with other models of DNA double-strand break induction. This study is part of ongoing research involving the delivery of a cytotoxic dose of radiation to cancer cells.