The effects of unprocessed wheat bran with and without drugs on the urinary excretion of calcium and oxalate in hypercalciuric subjects
Thompson, Angela Sue
MetadataShow full item record
To evaluate the efficacy of dietary fiber for patients with hypercalciuria, 30 g of dietary fiber as 78.2 g of wheat bran were given daily for three weeks to eight subjects with calcium oxalate stone. Control group consisted of nine subjects with calcium oxalate stone. Subjects in both groups followed a base diet of 400-500 mg calcium, less than 50 mg oxalate. Sodium, fat, and fiber content for the base diet were also restricted by providing lists of foods which are low in these nutrients. To determine if drugs would cause an additional reduction in urinary calcium, a thiazide medication and potassium citrate were added to the dietary treatment plans of both groups during the final phase of the study for one week. All subjects kept direct records for four weeks. Analysis of dietary records showed no significant difference between two groups for the intake of restricted nutrients. As a result of the fiber intake, urinary calcium decreased by 24 per cent but no change was observed in urinary oxalate excretion. A significant reduction in urinary oxalate was observed with the diet-alone control group, although no significant reduction was observed in urinary calcium of this group. The drugs promoted a significant reduction in urinary calcium but not in urinary oxalate excretion in both groups. We believe that fiber is effective in treating hyper- calciuria and may, in some cases, pre-empt the use of drugs. Drugs are effective and may be necessary in some patients who are nonresponsive to diet and fiber treatment. Since drugs and dietary fiber were effective in reducing urinary oxalate, it is recommended that dietary restrictions be implemented to prevent primary hyperoxaluria or secondary hyperoxaluria that is often produced when treating hypercalciuria.