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dc.contributor.advisorHagen, Timothyen_US
dc.contributor.authorWong, Aida Yukieen_US
dc.date.accessioned2015-06-11T14:29:18Z
dc.date.available2015-06-11T14:29:18Z
dc.date.issued2015-05
dc.identifier.urihttp://commons.lib.niu.edu/handle/10843/13725
dc.description.abstractMetAP 1 is a widespread enzyme found in Rickettsia prowazekii, a gram-negative bacteria that causes typhus and other diseases. As such, it is critical to find active sites of MetAP 1 on Rickettsia prowazekii in order to find inhibitors through protein-ligand binding for antibiotic drug candidacy and development. The program DockBlaster uses docking as a molecular modelling technique in order to predict the orientation of a ligand when binding to a protein. The PBD code for MetAP 1 (2B3H) from the RCSB database along with the corresponding ligand, glycerol (GOL), is submitted into DockBlaster. After virtual screening, it was determined that MetAP 1 has six pockets into which an inhibitor ligand can bind. In a future study, in vitro enzymatic assays for MetAP 1-inhibitor interactions will be conducted in order to screen for possible antibacterial activityen_US
dc.language.isoen_USen_US
dc.publisherNorthern Illinois Universityen_US
dc.rightsNIU theses are protected by copyright. They may be viewed from Huskie Commons for any purpose, but reproduction or distribution in any format is prohibited without the written permission of the authors.en_US
dc.subjectMetAP 1en_US
dc.subjectRickettsia prowazekiien_US
dc.subjectinhibitoren_US
dc.titleDocking of MetAP 1 for Inhibitor Candidacyen_US
dc.type.genreConference Posteren_US
dc.typeTexten_US
dc.contributor.departmentDepartment of Chemistry and Biochemistryen_US
dc.description.degreeB.A. (Bachelor of Arts)en_US


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