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dc.contributor.authorCarnahan, Jon W.
dc.contributor.authorKwok, Kaho
dc.contributor.authorCarr, John E.
dc.contributor.authorWebster, Gregory K.
dc.date.accessioned2013-03-06T19:03:31Z
dc.date.available2013-03-06T19:03:31Z
dc.date.issued2006
dc.identifier.citationKwok, K.; Carr, J. E.; Webster, G. K.; Carnahan, J. W. Determination of active pharmaceutical ingredients by heteroatom selective detection using inductively coupled plasma mass spectrometry with ultrasonic nebulization and membrane desolvation sample introduction. (2006) Appl. Spectrosc., 60: 80–85.en_US
dc.identifier.issn0003-7028
dc.identifier.urihttp://commons.lib.niu.edu/handle/10843/13504
dc.identifier.urihttp://hdl.handle.net/10843/13504
dc.description.abstractThe combination of ultrasonic nebulization with membrane desolvation (USN-MD) is utilized to determine active pharmaceutical ingredients (API) by heteroatom inductively coupled mass spectroscopy (ICP-MS) detection. Ultrasonic nebulization provides efficient sampling while use of the membrane desolvator acts to reduce solvent-based interferences. This approach reduces interferences sufficiently so that a standard argon ICPquadrupole MS can be utilized. Examined APIs and associated heteroatoms included: phosphomycin (P), amoxicillin (S), chlorpropamide (Cl), and ofloxacin (F). The optimum plasma r.f. powers for P, S, and Cl were in the 1000 to 1200 watts range. The high ionization energy of F required that the plasma be operated at 1500W. The 16O2 þ interference at mass 32 precluded determinations using the sulfur-32. The sulfur-34 (4.2% natural isotopic abundance), however, was relatively free of isobaric interferences. Interferences were relatively small at the mass 35 isotope of Cl, but increased with higher ICP r.f. powers. Overlaps were significant at the masses of monoisotopic species, fluorine-19 and phosphorus-31. Detection limits for P, S, Cl, and F of 2, 3, 90, and 3000 ng/mL, respectively, were generally lower than those produced with other quadrupole systems and comparable to or better than values published utilizing high-resolution instruments.en_US
dc.language.isoen_USen_US
dc.publisherOptical Society of Americaen_US
dc.subjectultrasonic nebulizationen_US
dc.subjectmembrane desolvationen_US
dc.subjectUSN-MDen_US
dc.subjectinductively coupled plasma mass spectrometryen_US
dc.subjectICP-MSen_US
dc.subjectelemental analysisen_US
dc.subjectheteroatom determinationen_US
dc.subjectpharmaceuticalen_US
dc.subjectdirect solution introductionen_US
dc.titleDetermination of Active Pharmaceutical Ingredients by Heteroatom Selective Detection Using Inductively Coupled Plasma Mass Spectrometry with Ultrasonic Nebuilization and Membrane Desolvation Sample Introductionen_US
dc.typeArticleen_US
dc.contributor.departmentDepartment of Chemistry and Biochemistry


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