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dc.contributor.authorCalvo, Ana M.
dc.contributor.authorWilson, R.A.
dc.contributor.authorChang, P.K.
dc.contributor.authorKeller, N.P.
dc.date.accessioned2013-02-14T18:54:52Z
dc.date.available2013-02-14T18:54:52Z
dc.date.issued2004-09
dc.identifier.citationWilson R.A., Calvo A.M., Chang P-K and Keller N.P. Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus/plant interaction. Microbiology. 2004.150:2881-8.en_US
dc.identifier.issn1350-0872
dc.identifier.urihttp://commons.lib.niu.edu/handle/10843/13425
dc.identifier.urihttp://hdl.handle.net/10843/13425
dc.description.abstractIn the mycotoxigenic oilseed pathogens Aspergillus flavus and Aspergillus parasiticus and the model filamentous fungus Aspergillus nidulans, unsaturated fatty acids and their derivatives act as important developmental signals that affect asexual conidiospore, sexual ascospore and/or sclerotial development. To dissect the relationship between lipid metabolism and fungal development, an A. parasiticus D12-desaturase mutant that was unable to convert oleic acid to linoleic acid and was thus impaired in polyunsaturated fatty acid biosynthesis was generated. The D12-desaturase mutant demonstrates delayed spore germination, a twofold reduction in growth, a reduced level of conidiation and complete loss of sclerotial development, compared to the wild-type. Host colonization is impaired, as reflected by a decrease in conidial production on live peanut and corn seed by the mutant compared to the wild-type. Similarly, the previously isolated A. nidulans D12-desaturase mutant has reduced colonization capabilities compared to the wild-type. Therefore, desaturation mutants display a key requisite that affords a genetic solution to oilseed crop contamination by mycotoxigenic Aspergillus species: a reduction in the production of conidia, the infectious particle of the pathogenic aspergilli.en_US
dc.language.isoenen_US
dc.publisherSociety for General Microbiologyen_US
dc.subjectAspergillus parasiticusen_US
dc.subjectlipid metabolismen_US
dc.subjectmycotoxigenic oilseed pathogensen_US
dc.titleCharacterization of the Aspergillus parasiticus delta12-desaturase Gene: A Role for Lipid Metabolism in the Aspergillus/plant Interactionen_US
dc.typeArticleen_US
dc.altlocation.urihttp://dx.doi.org/10.1099/mic.0.27207-0en_US
dc.contributor.departmentDepartment of Biological Sciences


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